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My disease amp settings — Line 6 Spider iv 75

The Left guitar tone for “My disease”, dialed in for a Line 6 Spider iv 75 with a Kramer Striker HSS. Studio cut, My Disease (Post-grunge / alternative metal heavy riff)

Original rig

High-gain tube heads (Peavey 5150 / Mesa Dual Rectifier architecture) + humbucker-equipped drop-tuned guitar + boost overdrive and noise gate

Aggressive, scooped post-grunge heavy high-gain wall of sound with tight palm mutes
Amp settings — Line 6 Spider iv 75
CHANNELMetal (Red LED)BOOSToff
GAIN 6 BASS 7 MID 4 TREBLE 6 REVERB 1 MASTER 4
KnobSetting (0–10)
Gain6
Bass7
Mid4
Treble6
Reverb1
Master4
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Guitar
PICKUPbridge TONE10 VOLUME10
Signal chain

01Boss SD-1 Super Overdrive

Used as a clean boost to tighten low-end tracking and focus mids into the high-gain channel

Level 8 · Tone 5 · Drive 1

02Boss NS-2 Noise Suppressor

Front of amp clamp to silence pickup hum and high-gain feedback during tight stops

Threshold 7 · Decay 2

03MXR M108s

Slight V-curve cut at 500Hz and 1kHz with a bump at 2kHz and 4kHz for punch and bite

31.25Hz 4 · 62.5Hz 6 · 125Hz 6 · 250Hz 5 · 500Hz 3 · 1kHz 4 · 2kHz 6 · 4kHz 6 · 8kHz 5 · 16kHz 4 · Gain 5 · Volume 5
Why these settings

The Spider IV 75 Metal Red voice provides cascaded modern high-gain; keeping its onboard gain around 6 prevents digital fizz when combined with the hot bridge humbucker on your Kramer Striker. The SD-1 is set as a classic front-end tightener (Drive at 1, Level high) rather than an amp distorter, leaving the amp to handle saturation without double-gain mud. The Spider IV 75 lacks a dedicated physical presence knob, so upper-register clarity is pushed using your MXR 10-band EQ's 2kHz and 4kHz sliders instead.

PRO TIPAnchor your palm directly against the bridge saddles on the low strings to get that percussive, chugging thud without choking out note decay.

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These settings are for a Line 6 Spider iv 75. ToneAdapt matches any song to whatever amp, guitar and pedals you own — first match is free.

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