Layla amp settings — Fender Mustang LT25

The Eric Clapton guitar tone for “Layla”, dialed in for a Fender Mustang LT25 with a Squier Affinity Stratocaster. Studio recording, Derek & The Dominos (1970) — iconic main riff

Original rig

1956 Fender Stratocaster 'Brownie' (neck pickup) → 1957 Fender Champ (5W tweed tube combo cranked wide open)

Warm, singing overdrive with rolled-off treble, vocal midrange, and creamy sustain from a cranked small tube amp

Amp settings — Fender Mustang LT25

CHANNEL'50s Champ amp modelBRIGHToff

Knob	Setting (0–10)
Gain	8
Bass	5
Treble	4
Reverb	2
Master	7

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Guitar

PICKUPneck TONE6 VOLUME10

Why these settings

The Mustang LT25's ''50s Champ' model emulates Clapton's cranked small tweed combo, delivering genuine power-tube style overdrive straight from the amp. The LT25 faceplate has no mid or presence controls, so shape the vocal midrange by rolling the Strat's tone knob down to 6 and keeping the amp's treble at 4 to eliminate single-coil harshness.

PRO TIPClapton used the neck pickup with the guitar tone rolled back slightly into a cranked 5W Champ; dig in hard with the pick near the middle pickup to produce that vocal, flute-like bloom on sustained notes.

Get this tone on your amp

These settings are for a Fender Mustang LT25. ToneAdapt matches any song to whatever amp, guitar and pedals you own — first match is free.

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Song, artist and gear names are used to identify the tone being matched; ToneAdapt is not affiliated with or endorsed by the artists or manufacturers mentioned. Settings are AI-generated starting points — trust your ears.