Tone library / Derek And The Dominos / Layla

Layla amp settings — Fender Mustang LT25

The Derek And The Dominos guitar tone for “Layla”, dialed in for a Fender Mustang LT25 with a Ibanez GIO GRG170DX. Studio version, Layla and Other Assorted Love Songs (1970) - Iconic opening riff and lead

Original rig

1956 Fender Stratocaster ('Brownie') plugged straight into a cranked 1950s Fender Tweed Champ (5F1)

Compressed, raw, mid-focused small-tweed amp overdrive with sharp single-coil bite

Amp settings — Fender Mustang LT25

CHANNEL'50s Champ (or '57 Deluxe preset model)BRIGHToffBOOSToff

Knob	Setting (0–10)
Gain	8
Bass	3
Treble	7
Reverb	1
Master	6

Don’t have a Fender Mustang LT25? See this song on other amps → Match your own rig →

Guitar

PICKUPbridge+middle TONE9 VOLUME10

Why these settings

Clapton generated the iconic opening tone by maxing a tiny single-ended Tweed Champ into natural power-tube saturation with a vintage Stratocaster. To match that raw low-wattage compression on your Mustang LT25, use the '50s Champ amp model with high gain and tight bass (the LT25 faceplate features only Gain, Volume, Treble, and Bass, with Mid and Presence physically absent and thus set to null). Using position 4 (bridge + middle) on your HSH Ibanez taps into the single-coil quack and upper-mid bite of Clapton's 1956 Strat.

PRO TIPDig in hard near the bridge with your pick; the original Champ tone gets its signature chirpy attack and bloom entirely from aggressive right-hand dynamics pushing the small speaker cone.

Get this tone on your amp

These settings are for a Fender Mustang LT25. ToneAdapt matches any song to whatever amp, guitar and pedals you own — first match is free.

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Song, artist and gear names are used to identify the tone being matched; ToneAdapt is not affiliated with or endorsed by the artists or manufacturers mentioned. Settings are AI-generated starting points — trust your ears.