Tone library / Queens of the Stone Age / Little Sister

Little Sister amp settings — Blonde 2025120800082

The Queens of the Stone Age guitar tone for “Little Sister”, dialed in for a Blonde 2025120800082 with a Ibanez HSS. Studio version, Lullabies to Paralyze (2005)

Original rig

Ampeg V-4/VT-22 tube amps, Ovation Ultra GP with humbuckers, Boss SD-1 overdrive, tuned to C Standard

Dry, mid-heavy crunch with tight low-end and percussive attack — focused grind, not scooped metal
Amp settings — Blonde 2025120800082
GAIN 6 BASS 4 MID 7 TREBLE 5 PRESENCE 5 REVERB 0 MASTER 5
KnobSetting (0–10)
Gain6
Bass4
Mid7
Treble5
Presence5
Reverb0
Master5
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Guitar
PICKUPbridge TONE6 VOLUME10
Why these settings

The Blonde 2025120800082 is an unknown/unverified amp model, so I've provided neutral mid-forward settings that prioritize the QOTSA character: boosted mids at 7, restrained bass at 4 to avoid mud in C Standard tuning, and rolled-back tone knob to 6 to approximate Homme's darker, less brittle attack. Your HSS bridge humbucker will get close to his Ovation humbuckers — gain at 6 gives focused crunch without fizz. Reverb is zero; the original is bone dry.

PRO TIPHomme's percussive attack comes from aggressive palm muting and picking right over the bridge pickup pole pieces — dig in hard on downstrokes and let the muted notes thump. If you can tune to C Standard (C-F-Bb-Eb-G-C), do it; the riff loses its weight in standard tuning.

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These settings are for a Blonde 2025120800082. ToneAdapt matches any song to whatever amp, guitar and pedals you own — first match is free.

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